姜凯


研究员/ jiangk@ynu.edu.cn/化学小分子的筛选与应用开发

个人简历:


2007年毕业于四川农业大学 农学院,理学学士;

2010年毕业于四川农业大学 水稻研究所,理学硕士;

2014年毕业于东京大学 农学生命研究科,农学博士;

2014年3月至2018年8月担任特任研究员/特任助教于东京大学从事科研工作;

2018年9月至2023年11月担任研究助理教授/副教授于南方科技大学从事科研工作;

2023年12月入职云南大学生命科学研究中心/生命科学学院担任研究员、课题组长(PI)。


研究内容:


姜凯博士主要从事植物激素信号转导和植物生长发育机制的研究工作。交叉性地运用经典遗传学、化学遗传学、结构生物学以及计算化学等多学科方法,湿实验和干实验结合的策略,从事小分子化合物的筛选和理性设计开发。借助小分子化合物进一步揭示信号转导和生长发育机制,推动基础科学研究。同时,紧密结合农业生产实践,开发植物生长调节剂。

课题组主要研究方向:

1)活性小分子化合物的高通量筛选及其作用机制研究;

2)运用化学遗传学方法研究植物生长发育和表观遗传调控机制;

3)新型植物生长调节剂的开发及其在农业中的应用研究。


招生专业方向:生物化学与分子生物学


论文发表(*第一作者,#通讯作者)


通讯/一作(含共同):

1. Aizezi Y, Zhao H, Zhang Z, Bi Y, Yang Q, Guo G, Zhang H, Guo H,Jiang K#and Wang Z#. Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY in Arabidopsis.Plant Cell.2023, https://doi.org/10.1093/plcell/koad299

2. Xie Y, Zhu Y, Wang N, Luo M, Ota T, Guo R, Yu Z, Aizezi Y, Zhang L, Zhang Y, Bao H, Wang Y, Zhu Z, Huang A, Zhao Y, Asami T, Huang H, Guo H#, andJiang K#. Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation.Proceedings of the National Academy of Sciences U.S.A. 2022, 119 (49) e2209256119.

3. Aizezi Y, Shu H, Zhang L, Zhao H, Peng Y, Lan H, Xie Y, Li J, Wang Y, Guo H#, andJiang K#. Cytokinin regulates apical hook development via the coordinated actions of EIN3/EIL1 and PIF transcription factors in Arabidopsis.Journal of Experimental Botany. 2022, 73(1), 213-227.

4.Jiang K*, Otani M*, Shimotakahara H, Yoon JM, Park SH, Miyaji T, Nakano T, Nakamura H, Nakajima M, Asami T#. Substituted phthalimide AC94377 is a selective agonist of the gibberellin receptor GID1.Plant Physiology. 2017, 173(1):825-835.

5.Jiang K#, Guo H, and Zhai J#. Interplay of phytohormones and epigenetic regulation: A recipe for plant development and plasticity.Journal of Integrative Plant Biology. 2023, 65(2):381-398.

6. Zhu Y, Li H, Su Q, Wen J, Wang Y, Song W, Xie Y, He W, Yang Z,Jiang K#, Guo H#. A phenotype-directed chemical screen identifies ponalrestat as an inhibitor of the plant flavin monooxygenase YUCCA in auxin biosynthesis.Journal of Biological Chemistry. 2019, 294(52): 19923-19933.

7. Aizezi Y, Xie Y, Guo H#, andJiang K#. New wine in an old bottle: utilizing chemical genetics to dissect apical hook development.Life. 2022, 12(8), 1285.

8.Jiang K*, Wang J*, Ito S, Takahashi I, Ohta T, Murase K, Nakajima M, Guo H, Takayama S, Asami T#. Analysis of the physiological roles and mode of actions of phthalimides as GA signal regulator in rice.Journal of Plant Growth Regulation. 2022, 42:2637–2645.

9. Takeuchi J*,Jiang K*, Hirabayashi K*, Imamura Y, Wu Y, Xu Y, Miyakawa T, Nakamura H, Tanokura M, Asami T#. Rationally Designed Strigolactone Analogs as Antagonists of the D14 Receptor.Plant and Cell Physiology. 2018, 59(8):1545-1554.

10.Jiang Kand Asami T#. Chemical regulators of plant hormones and their applicationsin basic research and agriculture.Bioscience Biotechnology and Biochemistry. 2018, 82(8):1265-1300.

11.Jiang K*, Shimotakahara H*, Luo M*, Otani M, Nakamura H, Moselhy SS, Abualnaja KO, Al-Malki AL, Kumosani TA, Kitahata N, Nakano T, Nakajima M, Asami T#. Chemical screening and development of novel gibberellin mimics.Bioorganic & Medicinal Chemistry Letters. 2017, 27(16):3678-3682.

12.Jiang K, Kurimoto T, Seo EK, Miyazaki S, Nakajima M, Nakamura H, Asami T#. Development of Inhibitors of Salicylic Acid Signaling.Journal of Agricultural and Food Chemistry. 2015, 63(32):7124-33.

13.Tian M*,Jiang K*, Takahashi I, Li G#. Strigolactone-induced senescence of a bamboo leaf in the dark is alleviated by exogenous sugar.Journal of Pesticide Science. 201 8,43(3):173-179.


共同作者

1. Liu C, Hao D, Sun R, Zhang Y, Peng Y, Yuan Y,Jiang K, Li W, Wen X#, and Guo H#. Arabidopsis NPF2.13 functions as a critical transporter of bacterial natural compound tunicamycin in plant-microbe interaction. 2023, 238(2):765-780.New Phytologist.

2. Liu L*, Song W*, Huang S,Jiang K, Moriwaki Y, Wang Y, Men Y, Zhang D, Wen X, Han Z, Chai J#, Guo H#. Extracellular pH sensing by plant cell-surface peptide-receptor complexes.Cell. 2022, 185(18), 3341-3355.

3. Zheng L, Meng J,Jiang K, Lan H, Wang Z, Lin M, Li W, Guo H, Wei Y#, and Mu Y#. Improving protein-ligand docking and screening accuracies by incorporating a scoring function correction term.Briefings in Bioinformatics. 2022, 23(3), 1–15.

4. Watanabe D*, Takahashi I*, Jaroensanti-Tanaka N, Miyazaki S,Jiang K, Nakayasu M, Wada M, Asami T, Mizutani M, Okada K, Nakajima M. The apple gene responsible for columnar tree shape reduces the abundance of biologically active gibberellin.The Plant Journal. 2021, 105:1026-1034.

5. Nakamura H*, Hirabayashi K*, Miyakawa T, Kikuzato K, Hu W, Xu Y,Jiang K, Takahashi I, Niiyama R, Dohmae N, Tanokura M, Asami T.#. Triazole ureas covalently bind to strigolactone receptor and antagonize strigolactone responses.Molecular Plant. 2019, 12(1):44-58.

6. Jamil M, Kountche BA, Haider I, Guo X, Ntui VO, Jia KP, Ali S, Hameed US, Nakamura H, Lyu Y,Jiang K, Hirabayashi K, Tanokura M, Arold ST, Asami T, Al-Babili S#. Methyl phenlactonoates are efficient strigolactone analogs with simple structure.Journal of Experimental Botany. 2018, 69(9):2319-2331.

7. Zhou Y, Zhong Y, Li L,Jiang K, Gao J, Zhong K#, Pan M#, and Yan B. A multifunctional chitosan-derived conformal coating for the preservation of passion fruit.LWT-Food Science and Technology. 2022, 163, 113584.

8. Takahashi I,Jiang K, and Asami T#. Counteractive effects of sugar and strigolactone on leaf senescence of rice in darkness.Agronomy. 2021, 11(6), 1044.

9. Ito S,Jiang K, and Asami T#. Chapter 7: Plant hormone cross-talk with a focus on strigolactone and its chemical dissection in riceSpringer book: Rice Genomics, Genetics and Breeding 2018.

10. Miyazaki S,Jiang K, Kobayashi M, Asami T, Nakajima M#. Helminthosporic acid functions as an agonist for gibberellin receptor.Bioscience Biotechnology and Biochemistry. 2017, 81(11):2152-2159.

11. Li G, Pan L,Jiang K, Takahashi I, Nakamura H, Xu Y, Asami T#, Shen R#. Strigolactone are involved in sugar signaling to modulate early seedling development in Arabidopsis.Plant Biotechnology. 2016, 33(2): 87-97.(封面文章)

12. Oh K#andJiang K. Synthesis of fluorescently labeled pyrazole derivative inducing a triple response in Arabidopsis seedlings.Journal of Pesticide Science. 2022, 47(4), 203–207.


专利申请:


1.杂环苯甲酰胺类化合物及其在促进植物生长发育中的应用,2022.01.20,中国,202210064182.3

2.NRT1.7基因表达的抑制剂在制备衣霉素吸收抑制剂中的应用,2021.06.19,中国,202110678271.2

3. PIFs的暗处稳定剂在促进双子叶植物顶端弯钩发育中的应用,2021.07.27,中国,202110581494.4

4.小分子化合物在促进植物生长发育中的应用,2021.05.17,中国,ZL202110040713.0

5.一种土甘草提取物在制备果蔬保鲜剂中的应用,2020.12.31,中国,202011596465.X

6.防治水稻稻瘟病和纹枯病的芽胞杆菌菌株, 2012.05.30,中国,ZL201010028132.7

7.防止水稻纹枯病和稻瘟病的链霉菌菌株,2012.04.25,中国,ZL201010028131.2


基金项目:


1.国家自然科学基金重点项目,32230008,植物顶端弯钩发育的细胞学和分子调控机制研究,2023.01-2027.12,骨干成员;

2.国家自然科学基金青年基金,21907049,以赤霉素受体GID1为靶标的信号调节剂的开发,2020.01-2022.12,主持;

3.广东省创新创业团队,2016ZT06S172,系统表观遗传学在作物改良中的应用,2017.07-2022.12,核心成员;

4.国家自然科学基金国际(地区)合作与交流项目,31911540070,运用化学生物学方法解析乙烯反应和RNA调控的分子机制,2019.04-2021.1 2,主要参与人;

5.日本JST大型研究推进事业项目CREST,利用植物激素间互作与化学生物学调控技术提高植物生物产量,2012.10-2017/3,参与人


联系方式:jiangk&ynu.edu.cn(&→@)


课题组诚招助理研究员、博士后、研究生,欢迎本科实习生!


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