崔清华


教授/ cuiqinghua@ynu.edu.cn/肿瘤的分子机制

个人简历

1991-1995 河北大学环境生物学专业 学士

1998-1998 中科院昆明动物研究所动物学专业 硕士

1998-2001 中科院环境生态研究中心环境生化专业 博士

2002-2004 美国马里兰大学 分子遗传学专业 博士后

2004-2009 美国范德堡大学癌症研究中心 研究科学家

2010-至今 云南大学 生化与分子生物学 教授

主要研究方向

本实验室关注肿瘤中的相关调控机理,以细胞株及临床病理样品为材料,集中关注Bcl-2家族在细胞凋亡及自噬中的调控作用及与线粒体代谢的关系。

实验室成员

余敏 副教授(研究方向:肿瘤微环境与细胞能量代谢的关系

林洁 副教授(研究方向: 抗肿瘤药物的作用机制研究)

丁磊 讲师

吕琦 实验师

在读研究生

蓝振玮,徐慧,敖鸿舜,熊先会,冯盈庭,曹珈琪,林文,马喜政


主要论文

  1. Lei Ding, Huan Gu, Zhenwei Lan, Qingchun Lei, Wenxue Wang, Jie Lin, Min Yu andQinghua Cui*2019.Down-regulation of cyclooxygenase-1 stimulates mitochondrial apoptosis through NF-kB signaling pathway in Colorectal Cancer Cells.Oncology Reports, 41: 559-569.

  2. Lei Ding, Zhenwei Lan, Xianhui Xiong, Hongshun Ao, Yingting Feng, Huan Gu, Min Yu,Qinghua Cui*2018. The dual role of microRNAs in colorectal cancer progression.Int. J. Mol. Sci..19(9):2791

  3. Kun YAO, Xu-feng FU, Xing DU, Yan LI, Shan-shan YANG, Min YU,Qing-hua CUI*.2018. PGC-1α coordinates with Bcl-2 to control the cell cycle in U251 cells through reducing ROS.JZUSB,19(6): 415-424

  4. Da-Jian He, Ling Wang, Zhi-Bi Zhang, Kun Guo, Jing-Zheng Li, Xie-Chao He,Qing-Hua Cui*, Ping Zheng*.2018. Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.Zoo. Res. 39(6): 1-10.

  5. Ran Wei, Qin Yang, Bing Han, Yan Li, Kun Yao, Zexi Chen, Jiaqi Zhou,Qinghua Cui*.2017. MicroRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.OncotargetDOI: 10.18632

  6. Xing Du, Xufeng Fu, Kun Yao, zhenwei Lan, Hui Xu,Qinghua Cui*, Elizabeth Yang*.2017. Bcl-2 delays cell cycle through mitochondrial ATP and ROS.Cell Cycle.16(7): 707-713

  7. Xu-feng Fu,Kun Yao,Xing Du,Yan Li,Xiu-yu Yang,Min Yu,Mei-zhang Li,Qing-hua Cui*.2016.PGC-1a regulates the cell cycle through ATP and ROS in CH1 cells.JZUSB,17(2):136-146.

  8. Wei Xu, Zexi Chen, Naeem Ahmed, Bing Han,Qinghua Cui*and Aizhong Liu*.2016. Genome-Wide Identification, Evolutionary Analysis, and Stress Responses of the GRAS Gene Family in Castor Beans.Int. J. Mol. Sci. 17, 1004;

  9. W. Wang, Y. Ye, J. Li, X. Li, X. Zhou, D. Tan, Y. Jin, E. Wu,Qinghua.Cuiand M. Wu.2014. Lyn Regulates Cytotoxicity in Respiratory EpithelialCells Challenged by Cigarette Smoke Extracts.Curr. Mol. Med.14,1-10

  10. Wei Xu#,Qinghua Cui#, Fei Li, Aizhong Liu*.2013. Transcriptome-wide identification and characterization of MicroRNAs from castor bean (Ricinus communis L.).PLOS ONE, 8 (7): e69995.

  11. Qinghua Cui, Mayda Valentin, Yelena Janumyan, Elizabeth Yang.2009. Bax-/- bak-/- cells exhibit p27Thr198 phosphorylation and autophagy.Autophagy5 (2): 263-264.

  12. Yelena Janumyan#,Qinghua Cui#, Ling Yan, Courtney G. Sansam, Elizabeth Yang.2008. Go function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation, revealing a novel role of BAX and BAK in quiescence regulation.JBC, 283: 34108; 34120.

  13. Ling Yan, Viviana A. Lavin, Leta R. Moser,Qinghua Cui, Cindy Kanies, and Elizabeth Yang.2008. PP2A Regulates the Pro-apoptotic Activity of FOXO1.JBC283: 7411; 7420.



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