李一青


研究员/ yiqingli@ynu.edu.cn/微生物活性天然产物

个人简历


教育经历

1984年-1988年,云南大学,有机化学,学士。

1996年-1999年,云南大学,有机化学,硕士。

2001年-2004年,云南大学,微生物天然产物化学,博士。


研究

2001年-至今,云南大学生命科学学院、教育部西南微生物多样性重点实验室。

2003年-2003年,德国HKI天然产物研究所,合作研究。

2009年-2010年,韩国建国大学,合作研究。


队主要方向

1.微生物药物资源的收集及活性筛选。

2.微生物医药、农药活性先导新化合物的发现。


近五年内承担的主要科研项目

主持完成国家自然科学基金:三七根际土壤放线菌抗根腐病原菌活性次生代谢产物研究”。


通讯或第一作者论文

1.Xindong Xu, Yang Zhao, Kang Bao, Cuiping Miao, Lixing Zhao, Youwei Chen, Shaohua Wu, Yiqing Li. Purification and characterization of anti-phytopathogenic fungi angucyclinone fromsoil‑derivedStreptomyces cellulosae.Folia Microbiologica, 2022,https://doi.org/10.1007/s12223-022-00957-6.

2.Junli Dong, Beibei He, Zhou Jiang, Ruinan Wang, Xiuli Zuo, Rui Zhan, Linfang Hu, Yiqing Li,Jing He. Characterization of the diastaphenazine/izumiphenazine C biosyntheticgene cluster from plant endophyteStreptomyces diastaticusW2.Microbial Biotechnology, 2022, 15(4): 1168-1177.

3. Xiao Chen, Jinmei Zou, Lei Li, Kang Bao, Yang Zhao, Cuiping Miao, Lixing Zhao, Youwei Chen,Yiqing Li.Cyclicpeptidesecondarymetabolites with antifungalactivity against root-rot pathogens ofPanax Notoginsengproduceded byStreptomyces yatensis.Chemistry of Natural Compounds, 2021, 57 (6): 1181-1183.

4.Xiao Chen,Linfang Hu, Xueshi Huang, Lixing Zhao, Cuiping Miao, Youwei Chen, Lihua Xu, Li Han,Yiqing Li. Isolation and characterization of new phenazine metabolites with antifungal activity againstroot-rotpathogens ofPanaxNotoginsengfromStreptomyces.Journal of Agricultural and Food Chemistry, 2019, 67, 11403-11407.

5.Linfang Hu, Xiao Chen, Li Han, Lixing Zhao, Cuiping Miao, Xueshi Huang, Youwei Chen, Ping Li,Yiqing Li.Two new phenazine metabolites withantimicrobialactivities from soil-derivedStreptomycesspecies.Journal of Antibiotics, 2019 72(3): 574-577.

6. XindongXu, Li Han,Lixing Zhao, Xiao Chen, Cuiping Miao, Linfang Hu, Xueshi Huang, Youwei Chen, Yiqing Li. Echinosporin antibiotics isolated fromAmycolatopsisstrain and their antifungal activity against root-rotpathogensof thePanax notoginseng.Folia Microbiologica, 2019, 64 (2), 171-175.

7. Longxia Wu,Xindong Xu,Xiao Chen,Cuiping Miao,Youwei Chen,Lihua Xu,Lixing Zhao, YiqingLi.Indole andtyraminealkaloidsproduced by anendophyticactinomyceteassociated withArtemisia annuaL.Chemistry of Natural Compounds,2017,53 (5): 999-1001.

8. Longxia Wu,Lixing Zhao, Xindong Xu,Li Han,Cuiping Miao,Youwei Chen,Xueshi Huang, LihuaXu,Yiqing Li.Secondarymetabolites of anendophyticactinomyceteisolated fromSedumsp.Chemistry of Natural Compounds, 2017,53 (2): 400-402.

9.Yiqing Li, Li Han, He Rong, Liya Li, Lixing Zhao, Longxia Wu, Lihua Xu, Yi Jiang,Xueshi Huang.Diastaphenazine, a new dimeric phenazine from an endophyticStreptomyces diastaticussubsp.Ardesiacus.Journal of Antibiotics,2015, 68(3): 210-212.

10. He Rong, Li Han, Yiqing Li, Lixing Zhao,Dan Zheng, Longxia Wu,Lihua Xu, Xueshi Huang, Yi Jiang.Newcyclic depsipeptide from an endophytic actinomycete.Chemistry of Natural Compounds,2015, 51(5): 926-928.

11. Dan Zheng, Li Han, Yiqing Li, Jun Li, He Rong, Qiao Leng, Yi Jiang, Lixing Zhao, Xueshi Huang. Isostreptazolin andsannaphenol,twonew metabolites fromStreptomyces sannanensis. Molecules, 2012, 17(1): 836-842.

12. Yiqing Li, Hyejin Park, Eunsu Han, Dongki Park. Inhibitory effect on B16/F10 mouse melanoma cell and HT-29 human colon cancer cell proliferation and cordycepin content of the butanol extract ofPaecilomyces militaris.Journal of Medicinal Plants Research. 2011, 5 (7): 1066-1071.

13. YiqingLi, Dan Zheng, Jun Li, Li Han, Xiaolong Cui, Li Lang, Minggang Li, Zhanyou Wang, Jiangyuan Zhao,Xueshi Huang. Sannanine, anewcytotoxicalkaloid fromStreptomycessannanensis. Journal of Antibiotics. 2009, 62(11): 647-648.

14. Yiqing Li, Xueshi Huang, Keishi Ishida, Armin Maier, Gerhard Kelter, Yi Jiang, Gundela Peschel, Klausdieter Menzel, Minggang Li, Mengliang Wen, Lihua Xu, Susanne Grabley, Heinzherbert Fiebig, Chenglin Jiang, Christian Hertweck and Isabel Sattler: Plasticity in gilvocarcin-typeC-glycoside pathways: discovery and antitumoral evaluation of polycarcin V fromStreptomyces polyformus.Organic & Biomolecular Chemistry. 2008, 19(6): 3601-3605.

15. Yiqing Li, Minggang Li, Wei Li, Jiangyuan Zhao, Zhanggui Ding, Xiaolong Cui, Mengliang Wen. Griseusin D, a New pyranonaphthoquinone derivative from a alkaphilicNocardiopsissp..Journal of Antibiotics. 2007, 60(12): 757-761.



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